Warren Thomas

Dr Warren Thomas

Dr. Warren ThomasDr. Warren Thomas
Academic Lead in Physiology, Perdana University – Royal College of Surgeons in Ireland

Email: warren.thomas@perdanauniversity.edu.my

Dr Warren Thomas is a graduate of the University of Wales, Aberystwyth and was awarded a PhD by the University of Reading in 1993. Dr Thomas has worked in the fields of animal and human health for more than 20 years. Dr Thomas has held research positions at the Institute for Animal Health, Compton and at King’s College London including a short-term scholarship to work in the Division of Digestive Medicine, University of California, Los Angeles. In 2002 Dr Thomas joined the Department of Molecular Medicine, Royal College of Surgeons in Ireland (RCSI) as a Research Fellow, with projects focused on investigating the role of steroid hormones in normal physiology and disease processes. Dr Thomas was appointed to the position of Lecturer at RCSI in 2008 and joined the Perdana University-RCSI faculty in 2015 as Academic Lead in Physiology.

1. Jennings CJ, Murer B, O’Grady A, Hearn LM, Harvey BJ, Kay EW, Thomas W (2015). Differential p16/INK4A cyclin-dependent kinase inhibitor expression correlates with chemotherapy efficacy in a cohort of 88 malignant pleural mesothelioma patients. Brit. J. Cancer 113, 69-75. PMID: 26057448.

2. Quinn S, Harvey BJ, Thomas W (2014). Rapid aldosterone actions on epithelial sodium channel trafficking and cell proliferation. Steroids 81, 43-48. PMID: 24269741.

3. Jennings CJ, Walsh PM, Deady S, Harvey BJ and Thomas W (2014). Malignant pleural mesothelioma incidence and survival in the Republic of Ireland 1994 to 2009. Cancer Epidemiol. 38, 35-41. PMID: 24394956.

4. Yusef YR, Thomas W and Harvey BJ (2014). Oestrogen increases ENaC activity via PKC signalling in renal cortical collecting ducts cells. Physiol. Rep. 2, e120120. PMID: 24872356.

5. CJ Jennings, B Murer, A O’Grady, BJ Harvey, EW Kay, W Thomas (2014). Steroid receptor co-activators and oestrogen receptor beta-1 isoform as survival biomarkers in malignant pleural mesothelioma. Anticancer Res. 34, 6206-6208.

6. Dooley R, Angibaud E, Yusef YR, Thomas W, Harvey BJ (2013). Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via protein kinase D1-phosphatidylinositol 4-kinaseIII trans-Golgi signalling in M1 cortical collecting duct cells. Mol. Cell. Endocrinol. 372, 86-95. PMID: 23541637.

7. Byrne JC, Ní Gabhann J, Stacey K, Coffey B, McCarthy E, Thomas W, Jefferies CA (2013). Btk is required for apoptotic cell uptake via regulating the phosphorylation and localisation of calreticulin. J. Immunol. 190, 5207-5215. PMID: 23596312.

8. Jennings CJ, O’Grady A, Cummins R, Murer B, Al-Alawi M, Madden SF, Mutti L, Harvey BJ, Thomas W, Kay EW (2012). Sustained expression of steroid receptor coactivator-2 SRC-2/TIF-2 is associated with better prognosis in malignant pleural mesothelioma. J. Thoracic Oncol. 7, 243-248. PMID: 22011668.

9. Dooley R, Harvey BJ, Thomas W (2012). Non-genomic actions of aldosterone: from receptors and signals to membrane targets. Mol. Cell. Endocrinol. 350, 223-234. PMID: 21801805.

10. Thomas W, Harvey BJ (2011). Mechanisms underlying rapid aldosterone effects on the kidney. Ann Rev Physiol. 73, 335-357. PMID: 20809792.

11. Hibbitts A, Lieggi N, McCabe O, Thomas W, Barlow J, O’Brien F, Cryan SA (2011). Screening of siRNA nanoparticles for delivery to airway epithelial cells using high content analysis. Therapeutic Delivery 2, 987-999. PMID: 22826866.

12. Caiazza F, McCarthy NS, Young LS, Hill AD, Harvey BJ, Thomas W (2011) Cytosolic hospholipase A2-alpha expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours. British J. Cancer. 104, 338-344. PMID: 21119660.

13. Dooley R, Harvey BJ, Thomas W (2011). The modulation of cell growth and survival by aldosterone. Front. Biosci. 16, 440-457. PMID: 21196180.

14. Pinton G, Thomas W, Bellini P, Manente AG, Favoni R, Harvey BJ, Mutti Moro L (2010). Estrogen receptor beta exerts tumor repressive functions in human malignant pleural mesothelioma via interference with EGFR activation and affects the response to gefitinib. PLoS One. 5, e14110. PMID: 21124760.

15. Nguyen TT, Ogbi M, Yu Q, Fishman J, Thomas W, Harvey BJ, Fulton D, Johnson JA (2010). Modulation of the delta protein kinase C interaction with the d-subunit of F1F0 ATP synthase in neonatal cardiac myocytes: Development of cell permeable, mitochondrial targeted inhibitor and facilitator peptides. J Biol Chem. 285, 22164-22173. PMID: 20460381.

16. Caiazza F, Harvey BJ, Thomas W (2010). Cytosolic phospholipase A2 activation correlates with HER2 over-expression and mediates oestrogen-dependent breast cancer cell growth. Mol. Endocrinol. 24, 953-968. PMID: 20211985.

17. Chotirmall SH, Greene CM, Oglesby IK, Thomas W, O’Neill SJ, Harvey BJ, McElvaney NG (2010). 17β-Estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor. Am. J. Resp. Crit. Care Med. 182, 62-72. PMID: 20378727.

18. Ní Gabhann J, Ben Larbi N, Higgs R, Brennan K, Thomas W, Damen JE, Krystal G, Jefferies CA (2010). Absence of SHIP-1 results in constitutive phosphorylation of TBK1 and enhanced TLR3-dependent IFN- production. J. Immunol. 184, 2314-2320. PMID: 20100929.

19. McEneaney V, Dooley R, Yusef YR, Keating N, Quinn U, Harvey BJ, Thomas W (2010). Protein Kinase D1 modulates aldosterone-Induced ENaC activity in a renal cortical collecting duct cell line. Mol. Cell. Endocrinol. 325, 8-17. PMID: 20434520.

20. McEneaney V, Dooley R, Harvey BJ, Thomas W (2010). Aldosterone-induced cell growth and ERK1/2 MAP kinase activation in M1 cortical collecting duct cells is Protein Kinase D1-dependent. J. Steroid Biochem. Mol. Biol. 118, 18-28. PMID: 19804826.

21. Thomas W, Dooley R, Harvey BJ (2010). Aldosterone as a renal growth factor. Steroids 75, 550-554. PMID: 19782095. 22. O’Mahony F, Thomas W, Harvey BJ (2009). Novel female sex-dependent actions of oestrogen in the intestine. J. Physiol. 587, 5039-5044. PMID: 19723780.

23. O’Mahony F, Alzamora R, Chung H-L, Thomas W, Harvey BJ (2009). Genomic priming of the anti-secretory response to estrogen in the rat distal colon throughout the estrous cycle. Mol. Endocrinol. 23, 1885-1899. PMID: 19846538.

24. Yang JZ, O’Flatharta C, Harvey BJ, Thomas W (2008). Membrane ER-dependent activation of PKC in endometrial cancer cells by estradiol. Steroids 73, 1110-1122. PMID: 18534651.

25. McEneaney V, Harvey BJ, Thomas W (2008). Aldosterone regulates ENaC subunit trafficking in renal cortical collecting duct cells through protein kinase D activation. Mol. Endocrinol. 22, 881-892. PMID: 18202152.

26. Thomas W, Caiazza F, Harvey BJ (2008). Estrogen, phospholipase A and breast cancer. Front. Biosci. 13, 2604-2613. PMID: 17981737.

27. Harvey BJ, Alzamora R, Stubbs AK, Irnaten M, McEneaney V, Thomas W (2008). Rapid responses to aldosterone in the kidney and colon. J. Steroid Biochem. Mol. Biol. 108, 310-317. PMID: 17951051.

28. Thomas W, McEneaney V, Harvey BJ (2008). Aldosterone-induced signalling and cation transport in the distal nephron. Steroids 73, 979-984. PMID: 18308353.

29. Thomas W, McEneaney V, Harvey BJ (2007). Aldosterone-stimulated PKC signalling cascades: from receptor to effector. Biochem. Soc. Trans. 35, 1049-1051. PMID: 17956276.

30. Thomas W, McEneaney V, Harvey BJ (2007). Rapid responses to steroid hormones in the kidney. Nephron Physiol. 107, 1-9. PMID: 17641544.

31. McEneaney V, Harvey BJ, Thomas W (2007). A mineralocorticoid receptor/EGFR trans-activation pathway mediates the rapid activation of protein kinase D by aldosterone in the M1 kidney cortical Collecting duct cell line. J. Steroid Biochem. Mol. Biol. 107, 180-190. PMID: 17681751.

32. Thomas W, Coen N, Faherty S, O’Flatharta C, Harvey BJ (2006). Estrogen induces phospholipase A2 activation through ERK1/2 to mobilize intracellular calcium in MCF-7 cells. Steroids, 71, 256-265. PMID: 16375935.

33. Lax AJ, Thomas W (2002). How bacteria could cause cancer: one step at a time. Trends Microbiol. 10, 293-299. PMID: 12088666.

34. Thomas W, Ascott ZK, Harmey D, Slice L, Rozengurt E, Lax AJ (2001). Escherichia coli cytotoxic necrotizing factor induces Rho dependent expression of the cyclooxygenase-2 gene. Infect. Immun. 69, 6839-6845. PMID: 11598057.

35. Thomas W, Pullinger GD, Lax AJ, Rozengurt E (2001). E. coli cytotoxic necrotizing factor and P. multocida toxin induce FAK autophosphorylation and Src association. Infect. Immun. 69, 5931-5935. PMID: 11500476.

36. Laidlaw SM, Anwar MA, Thomas W, Green P, Shaw K, Skinner MA (1998). Fowlpoxvirus encodes non-essential homologs of cellular alpha SNAP, PC-1 and an orphan human homolog of a secreted nematode protein. J. Virol. 72, 6742-6751. PMID: 9658122.

37. Sellwood R, Walton F, Thomas W, Burrows MR, Chesham J (1995). Expression of the SmpA outer membrane lipoprotein of Serpulina hyodysenteriae strain P18A in vivo. Vet. Microbiol. 44, 25-35. PMID: 7667904.

38. Thomas W, Sellwood R (1993). Molecular cloning, expression and DNA sequence analysis of the gene encoding the 16kDa outer membrane lipoprotein of Serpulina hyodysenteriae. Infect. Immun. 61, 1136-1140. PMID: 8432595.

39. Thomas W, Sellwood R (1992). Monoclonal antibodies to a 16kDa antigen of Serpulina hyodysenteriae. J. Med. Micro. 37, 214-220. PMID: 1518039.

40. Thomas W, Sellwood R, Lysons RJ (1992). A 16kDa antigen of the outer membrane of Serpulina hyodysenteriae. Infect. Immun. 60, 3111-3116.PMID: 1639479.

1. Aldosterone-induced signalling and the control of renal sodium conservation. This project is integrated into the Marie Curie-Sklodowska H2020 COST-ADMIRE action BM1301.

2. Survival biomarkers in malignant pleural mesothelioma. This project is supported by collaborations with the University of Hawaii (USA), University Piemonte Orientale (Italy), Trinity College Dublin (Ireland) and the National Cancer Registry of Ireland.