Prof Dr Raghu Varadarajan


Prof Dr Raghu Varadarajan


ProfRaghuProf Dr Raghu Varadarajan, MBBS, MCh, FRCS (Edinburgh), Fellowship, Abdominal Organ Transplantation (Columbia University, New York)
RCSI Lead in Surgery

Email: raghu@perdanauniversity.edu.my


Clinical

MBBS, Madras Medical College and University of Madras, Chennai, India, 1986
Internship, Government General Hospital, Chennai, India, 1987
Basic Surgical Training (Senior House Officer)
Middlesbrough General Hospital, UK, 1989-1991
Brighton General Hospital and Royal Sussex County Hospital, UK, 1993
Fellow of the Royal College of Surgeons, (FRCS), Edinburgh, 1992
Higher Surgical Training (Registrar)pg9a
Swindon and Marlborough NHS Trust, UK 1993-1996
University College Hospital, Galway, Ireland, 1996-1997
St Michaels Hospital and St Vincent’s Hospital, Dublin, Ireland, 1997-1998
St. Vincent’s University Hospital, Dublin, Ireland 1998-2002
Master of Surgery (MCh), National University of Ireland, 2004
Clinical Fellowship
Fellow, Abdominal Organ Transplant, Columbia University, New York Presbyterian Hospital, New York, 2003-2005
Clinical Practice
Consultant, Renal Transplant Surgery, Madras Medical Mission, Chennai, India, 2005-2006
Senior Consultant and Adjunct Associate Professor, Department of GI and Transplant Surgery,
Sri Ramachandra Medical Center, Chennai, India, 2009-2011
Consultant Hepatobiliary/Transplant Surgeon, Dr Kamakshi Memorial Hospital, Chennai, India, 2006-2014

Research

I took active interest in scientific research encouraged by the Department of Hepatobiliary and Liver Transplantation in Dublin and the final year was dedicated to laboratory and clinical research within the department. The Education and Research Centre was based at St Vincent’s University Hospital and headed by the Director, Dr Cliona O’Farrelly who has pioneered research in human liver immunology. My initial research with the group was to characterise by immunohistochemistry T and B-lymphocytes in the donor liver (passenger lymphocytes) and correlate the findings with the occurrence and severity of acute cellular rejection post transplantation. The results of the above study have been presented in local and international meetings and a paper is in the process of being submitted for publication.

I also investigated the role of nitric oxide in ischaemia and reperfusion injury during human orthotopic liver transplantation. NO metabolites and NO synthases were measured in donor and reperfusion biopsies in order to determine their impact on graft damage and outcome. The study, performed in the setting of human liver transplantation for the first time, demonstrated that liver allograft injury correlated well with reduced nitric oxide levels and eNOS expression and high peroxynitrite levels. The results of my research have been presented in a number of local and international meetings and have been published in international peer reviewed journals.

My research also enabled me to learn various laboratory techniques such as immunohistochemistry, apoptosis by TUNEL technique, nitric oxide analysis by chemiluminescence and Western Blot analysis. The nitric oxide study was the subject of my thesis submitted to University College Dublin for a higher degree (Master of Surgery), which was awarded in May 2004.

Academic

Teaching Experience

Registrar in Surgery, Swindon and Marlborough NHS Trust, UK, teaching undergraduate students from Southampton, 1993-1996

Registrar in Vascular Surgery, University College Hospital, Galway, Ireland, teaching undergraduate students and supervision of house officers and senior house officers, 1996-1997

Registrar in General, Hepatobiliary and Transplant Surgery, St Vincents University Hospital, Dublin, teaching undergraduates and supervision of house officers and senior house officers from University College Hospital, Dublin, Ireland, 1997-2002

Clinical Instructor and Fellow in Transplant Surgery, Columbia University Medical Center, New York, USA, teaching undergraduates and supervising residents, New York Presbyterian Hospital, New York, USA, 2003-2005

Adjunct Associate Professor in General and Transplant Surgery, Sri Ramachandra Medical Centre, India, teaching undergraduates and supervision of post graduate students from Sri Ramachandra University, Chennai, 2009-2011

Perdana University-Royal College of Surgeons in Ireland, as Associate Professor and RCSI Lead in Surgery, Kuala Lumpur, Malaysia, 2014 to present

Book Chapter

• Transperitoneal Laparoscopic Nephrectomy
Anand Khakhar, Raghu Varadarajan and Lloyd E Ratner
In Living Donor Organ Transplantation by Rainer WG Gruessner and Enrico Benedetti
Published by McGraw-Hill Professional, 2007; Chap 15.5.3:175-185

Original peer reviewed articles
• Reoxygenation Specific Activation of the Anti-Oxidant Transcription Factor Nrf2 Mediates Cytoprotective Gene Expression in Ischemia Reperfusion Injury
Martin O. Leonard, Niamh E. Kieran, Katherine Howell, Melissa J. Burne, Raghu Varadarajan, Saravanakumar Dhakshinamoorthy, Alan G Porter, Cliona O’Farrelly, Hamid Rabb & Cormac T Taylor

The FASEB Journal 2006; 20:2624-2626

• Utilization of extended donor criteria liver allografts maximizes donor use and patient access to liver transplantation
Renz JF, Kin C, Kinkhabwala M, Jan D, Varadarajan R, Goldstein M, Brown R Jr,
Emond JC

Annals of Surgery 2005 Oct; 242(4):556-63; discussion 563-5

• Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation
R Varadarajan, L Young, L Golden-Mason, N Nolan, P McLoughlin, J Geoghegan, O Traynor, G McEntee, JE Hegarty and C O’Farrelly

Transplantation 2004; 78:250-256

• Accessory left biliary duct draining into lesser curve of stomach
R Mascarenhas, J Mathias, R Varadarajan, J Geoghegan, O Traynor

Gut 2002 Dec; 51(6) 884

• Spontaneous hepatic rupture-a report of five cases
R Mascarenhas,R Varadarajan, J Geoghegan, O Traynor
Hepatopancreatobiliary International 2002 Vol 4;(4) 167-170

Abstracts resulting from presentations

• Critical care professionals’ knowledge and attitudes related to brain death, cadaveric organ donation and transplantation
WL Oo, JW Foong, JS Ong, MM Hossain, ND Baskaran, H Haron, Y Yusop, L Mansor, R Varadarajan

Ethical, Legal and Psychological Aspects of Transplantation, Rome, Italy, April 2016

• Knowledge and Attitudes of Critical Care Professionals towards Brain Death, Cadaveric Organ Donation and Transplantation
Ong Jea Sheng, James William Foong, Oo Wei Loon, Mohammad Moshaddeque Hossain, Nirmala Basakaran, Hasdy bin Haron, Yuzana Mohd. Yusop, Lela Yasmin Mansor, Raghu Varadarajan

International Liver Transplant Society, Seoul, Korea, May 2016

• Utilization of extended donor criteria liver allografts maximises donor utility and patient access to liver transplantation
JF Renz, C Kin, M Kinkhabwala, D Jan, R Varadarajan, M Goldstein, RS Brown and JC Emond

American Surgical Association, Florida, USA, April 2005

• Adult to adult liver transplantation for end stage liver disease complicated by hepatocellular carcinoma
R Varadarajan, JF Renz, M Kinkhabwala, L Dove, P Gaglio, RS Brown and JC Emond

Asian Pacific Association for the Study of the Liver, New Delhi, India, December 2004

• Systematic use of live donor liver transplant: differential impact on children and adults
R Varadarajan, JF Renz, M Kinkhabwala and JC Emond

Asian Pacific Association for the Study of the Liver, New Delhi, India, December 2004

• Activation of the nitric oxide pathway in early ischaemia reperfusion injury following human orthotopic liver transplantation
R Varadarajan, L Young, L Golden, N Nolan, P McLoughlin, J Geoghegan, O Traynor, G McEntee, JE Hegarty and C O’Farrelly

American Transplant Congress, Washington, USA, May 2003

• Early activation of the nitric oxide pathway following reperfusion in human orthotopic liver transplantation
R Varadarajan, L Young, L Golden, M Quinlan, N Nolan, P McLoughlin, J Geoghegan, O Traynor, G McEntee, JE Hegarty and C O’Farrelly

British Transplantation Society, London, UK, April 2003

• The nitric oxide-peroxynitrite pathway: a role in early ischaemia reperfusion injury following human orthotopic liver transplantation
R Varadarajan, L Young, L Golden, M Quinlan, N Nolan, P McLoughlin, J Geoghegan, O Traynor, G McEntee, JE Hegarty and C O’Farrelly

Surgical section of the Royal Academy of Medicine in Ireland, Dublin, Ireland, January 2003

• Early activation of the nitric oxide pathway following reperfusion in human orthotopic liver transplantation
R Varadarajan, L Young, L Golden, M Quinlan, N Nolan, P McLoughlin, J Geoghegan, O Traynor, G McEntee, JE Hegarty and C O’Farrelly.

Irish Society of Gastroenterology, Dublin, Ireland, November 2002

• Nitric oxide expression is reduced following reperfusion in human orthotopic liver transplantation
R Varadarajan, L Young, M Quinlan, P Mc Loughlin, J Geoghegan, O Traynor, G McEntee, JE Hegarty, C O’Farrelly

Irish Transplantation Society, Dublin, Ireland, March 2002

• Hepatic B cells: A role for rejection in human orthotopic liver transplantation?
R Varadarajan, C Gallagher, N Nolan, O Traynor, G McEntee, J Hegarty, J Geoghegan, C O’Farrelly

Society of Academic and Research Surgery, London, UK, January 2002

• Nitric oxide expression following reperfusion in human orthotopic liver transplantation
R Varadarajan, L Young, M Quinlan, P Mc Loughlin, J Geoghegan, O Traynor, G McEntee, JE Hegarty, C O’Farrelly

Society of Academic and Research Surgery, London, UK, January 2002

• Reduction in nitric oxide levels following reperfusion in human orthotopic liver transplantation
R Varadarajan, L Young, M Quinlan, P Mc Loughlin, J Geoghegan, O Traynor, G McEntee, JE Hegarty, C O’Farrelly

Conway Institute Festival of Research, Dublin, Ireland, September 2001

Irish Society of Immunology, Dublin, Ireland, September 2001

• Hepatic B cells: A role for rejection in human orthotopic liver transplantation?
R Varadarajan, C Gallagher, N Nolan, O Traynor, G McEntee, J Hegarty, J Geoghegan, C O’Farrelly

Conway Institute Festival of Research, Dublin, Ireland, September 2001

Irish Society of Immunology, Dublin, Ireland, September 2001

• Lymphocyte profile in the donor liver and variation in response to rejection following human orthotopic liver transplantation
R Varadarajan, C Gallagher, N Nolan, O Traynor, G McEntee, J Hegarty, J Geoghegan, C O’Farrelly

National Scientific Medical Meeting, Dublin, Ireland, April 2001

• Increased numbers of B but not T lymphocytes in donor liver is associated with acute cellular rejection post orthotopic liver transplantation
R Varadarajan, T Deignan, C Gallagher, N Nolan, O Traynor, G McEntee, J Hegarty, J Geoghegan, C O’Farrelly

Waterford Surgical October Club, Waterford, Ireland, October 2000

Irish Society of Gastroenterology, Dublin, Ireland, September 2000

• Management of post cholecystectomy bile duct injury
E Heffernan, R Varadarajan, J Mathias, E Carton, JG Geoghegan, O Traynor

Irish Society of Gastroenterology, Dublin, Ireland, September 2000

• 101 liver resections for metastatic colorectal carcinoma
S Connolly, A Brannigan, R Varadarajan, J Mathias, JG Geoghegan, O Traynor

Irish Society of Gastroenterology, Killarny, Ireland, May 2000

• Primary graft dysfunction: the Dublin experience
R Varadarajan and The Liver Unit, St. Vincent’s Hospital, Dublin

Republic of Ireland and United Kingdom Meet, Dublin, Ireland, September 1999

• Recurrence of Crohn’s disease after colonic resection and ileo-colic anastamosis
JF Quinlan, CP Delaney, H O’Grady, R Varadarajan, DP O’Donoghue, JMP Hyland

Sylvester O’Halloran Meeting, Limerick, Ireland, March 1999

• Spontaneous Rupture of Liver in Pregnancy
JF Quinlan, J Mathias, CP Delaney, R Varadarajan, O Traynor

Royal Academy of Medicine in Ireland, Dublin, November 1998

• Recurrence of Crohn’s disease after colonic resection and ileo-colic anastamosis
JF Quinlan, CP Delaney, H O’Grady, R Varadarajan, DP O’Donoghue, JMP Hyland

Irish Society of Gastroenterology, Dublin, Ireland, November 1998

Attitudes towards organ donation among different ethnic groups in Malaysia
Amanda Villiers-Tuthill, Jayakiran Radhakrishnan, Mehala Balasubramaniam, Nurul Farhana Binti Baharudin, Raghu Varadarajan, Karen Morgan
Manuscript submitted for review

Can Knowledge and Attitudes of Critical Care Professionals Influence Organ
Donation? – A Malaysian Perspective

Ong Jea Sheng, James William Foong, Oo Wei Loon, Mohammad Moshaddeque Hossain, Nirmala Basakaran, Hasdy bin Haron, Yuzana Mohd. Yusop, Lela Yasmin Mansor, Raghu Varadarajan
Paper accepted for oral presentation, The Transplant Society, Hong Kong, August 2016
Manuscript in progress

Albumin Metabolism in Health with Potential for Intervention in Disease – A Literature Review
Loshini Rajentharan, Thamayanthy Murugesu, Raghu Varadarajan
Manuscript in progress

Out-patient Breast Clinic Waiting Room Survey: Malaysian Sub-Study
Study in progress