Kamalan Jeevaratnam


Dr. Kamalan Jeevaratnam

Dr. Kamalan JeevaratnamDr. Kamalan Jeevaratnam
Research Fellow

DAHP, DVM, MMedSc (Mal); PhD (Cambridge); MRCVS (UK)
Email: kamalan@pu-rcsi.edu.my

Dr. Kamalan Jeevaratnam is a Research Fellow at PU-RCSI. As an academician, he has previously delivered lectures and practical session to both medical and veterinary students at the International Medical University, University Putra Malaysia and the University of Cambridge, UK.

His research interest includes integrative physiology, novel therapeutic agent and biomarker discoveries, microsurgical techniques for animal models as well as medical education. His present work concerns the use integrative physiology techniques to elucidate mechanism of cardiac arrhythmia and developing risk stratification strategies for clinical practice. The work involves the identification and characterization of novel ion channel and receptor genes through functional analysis using gene-targeting to the invasive analysis of cardiac arrhythmia substrates in patients. The fact that measurements made in humans can be also be obtained in GM mice highlights the translational aspects of his research. He works with a series of novel GM mice with targeted disruptions in respectively the potassium channel gene, KCNE1, and the sodium channel gene, Scn5a, and the ryanodine receptor, RyR2 He has authored several internationally peer-reviewed journals and presented many scientific sessions around the world. He is also actively involved in research collaboration with the University of Cambridge, UK; University of Manchester, UK; Xian Jiantong University, China; International Medical University, Malaysia; University Putra Malaysia, MARDI and Aarhaus University, Denmark in the following areas: mechanisms of cardiac arrhythmia, biomarker discovery for gestational hypertension and muscular dystrophy, studies on neuropathic pain and chronic inflammatory models, medical education research (PBLs and admission processes) and drug discovery. He has authored several internationally peer-reviewed journals and presented at many different scientific sessions around the world.

Dr. Jeevaratnam is also a keen public speaker, debater and judge, having previously debated for the prestigious Cambridge Union and been chief judge for several international competitions. He has been involved in United Nations debate program as well as spoken as a youth leader on topics involving media and national development at the Perdana Leadership Foundation. He regular develops training modules for speech and interpersonal skills as well as trains corporate staff and university students. Dr. Jeevaratnam’s industry experience includes extensive work in training technical sales talent as well as developing key account management schemes in Malaysia for Colgate Palmolive’s pet nutrition division, Hill’s Pet Nutrition Incorp. Dr. Jeevaratnam also consulted as a business development advisor for H&G Strategic Communication, based in Malaysia which specialises in executive training programs for private companies, local schools and universities. He was their strategic consultant when negotiating funding for international and local programs with a regional investment bank. Dr. Jeevaratnam a Malaysian, holds a PhD from the University of Cambridge, a MMedSc from International Medical University and the Doctor of Veterinary Medicine from University Putra Malaysia, He was admitted to the Royal College of Veterinary Surgeons, UK in 2011 by examination. He was also the recipient of numerous scholarships and awards namely the Cambridge Commonwealth Trust Award (2008-2010), Maxis Communications Scholarship for Excellence Program (2008-2011), Nicola Emmerson Trust Award (2010-2011) and FFM Best Research Award (2005).

Pau A, Jeevaratnam K, Chen SY, Fall AA, Khoo C, Nadarajah VD. The Multiple Mini Interview (MMI) for students selection in health professions training – a systematic review. Medical Teacher– early online. http://informahealthcare.com/doi/abs/10.3109/0142159X.2013.829912

King JH, Wickramarachchi C, Kua K, Du Y, Jeevaratnam K, Matthews HR, Grace AA, Huang CL, Fraser JA. Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation. Cardiovasc Res. 2013 Sep 1;99(4):751-9.

Zhang Y, Wu J, Jeevaratnam K, King JH, Guzadhur L, Ren X, Grace AA, Lei M, Huang CL, Fraser JA. Conduction Slowing Contributes to Spontaneous Ventricular Arrhythmias in Intrinsically Active Murine RyR2-P2328S Hearts. J Cardiovasc Electrophysiol. 2012 Sep 17.

Jeevaratnam K, Rewbury R, Zhang Y, Guzadhur L, Grace AA, Lei M, Huang CL. Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a(+/-) hearts: The effects of ageing and sex. Mech Ageing Dev. 2012 Sep;133(9-10):591-9.

Duehmke RM, Pearcey S, Stefaniak JD, Guzadhur L, Jeevaratnam K, Costopoulos C,Pedersen TH, Grace AA, Huang CL. Altered re-excitation thresholds and conduction of extrasystolic action potentials contribute to arrhythmogenicity in murine models of long QT syndrome. Acta Physiol (Oxf). 2012 Nov;206(3):164-77.

Guzadhur L, Jiang W, Pearcey SM, Jeevaratnam K, Duehmke RM, Grace AA, Lei M, Huang CL. The age-dependence of atrial arrhythmogenicity in Scn5a+/- murine hearts reflects alterations in action potential propagation and recovery. Clin Exp Pharmacol Physiol. 2012 Jun;39(6):518-27.

Jeevaratnam K, Poh Tee S, Zhang Y, Rewbury R, Guzadhur L, Duehmke R, Grace AA, Lei M, Huang CL. Delayed conduction and its implications in murine Scn5a(+/-) hearts: independent and interacting effects of genotype, age, and sex. Pflugers Arch. 2011 Jan;461(1):29-44.

Zhang Y, Fraser J, Jeevaratnam K, Hoa X, Hothi S, Grace A, lei M, Huang LH. Acute atrial arrhythmogenicity and altered Ca2+ homeostasis in murine RyR2-P2328S hearts. Cardiovasc Res. 2011 Mar 1;89(4):794-804.

Jeevaratnam K, Nadarajah VD, Judson JP, Nalliah S, Abdullah MF. Periodic assessment of plasma sFlt-1 and PlGF concentrations and its association with placental morphometry in gestational hypertension (GH) – a prospective follow-up study. BMC Pregnancy Childbirth. 2010 Sep 28;10:58

Guzadhur L, Pearcey SM, Duehmke RM, Jeevaratnam K, Hohmann AF, Zhang Y, Grace AA, Lei M, Huang CL. Atrial arrhythmogenicity in aged Scn5a+/KPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction. Pflugers Arch. 2010 Aug;460(3):593-601.

Jeevaratnam K, Zhang Y, Guzadhur L, Duehmke RM, Lei M, Grace A, Huang LH. Difference is sinoatrial and atrioventricular function with age and sex attributable to the SCN5a mutation in a murine cardiac model. Acta Physiol(Oxf). 2010 Sep;200(1):23-33.

Dr. Kamalan Jeevaratnam’s research interest includes mechanisms of cardiac arrhythmia, biomarker discovery for gestational hypertension and muscular dystrophy, studies on neuropathic pain and chronic inflammatory models, medical education research (PBLs and admission processes) and drug discovery. His present work concerns the use integrative physiology techniques (Langendorff preparation, electrocardiograms, invasive cardiac electrophysiology etc.) to elucidate mechanism of cardiac arrhythmia and developing risk stratification strategies for clinical practice. The work involves the identification and characterization of novel ion channel and receptor genes through functional analysis using gene-targeting to the invasive analysis of cardiac arrhythmia substrates in patients. He works with a series of novel GM mice with targeted disruptions in a variety of ion channels to provide the translational aspect of his work. He is trained in microsurgical techniques in small rodents and also performs large animal surgeries for research purpose.
Collaborations :

  • International Medical University, Malaysia
  • Malaysian Agricultural Research and Development Institute (MARDI), Selangor, Malaysia
  • University Putra Malaysia, Selangor, Malaysia
  • General Hospital Kuala Lumpur, Wilayah Persekutuan, Malaysia
  • University of Cambridge, UK
  • Institute of Cardiovascular Sciences, University of Manchester, UK
  • Xi’an Jiaotong University, Xi’an, China
  • Papworth Hospital, Cambridge, UK