Brian Patrick Kirby


Dr. Brian Patrick Kirby

Dr. Brian Patrick KirbyDr. Brian Patrick Kirby
Lecturer, Pharmacology

Email: briankirby@pu-rcsi.edu.my

Prior to joining PU-RCSI in 2011, Dr. Kirby worked as Senior Lecturer in Pharmacology in the School of Pharmacy in the Royal College of Surgeons in Ireland.  He obtained his pharmacy degree from Trinity College Dublin in 1995 and following his internship, registered as a pharmacist in Ireland.  He then pursued a PhD in neuropharmacology with Prof G Shaw in Trinity College Dublin and subsequently worked as a post-doctoral scientist at the Department of Experimental Psychology in the University of Oxford.  While here he lectured on neurodegenerative disorders in the MSc in Neuroscience course.

Dr. Kirby joined RCSI in 2003 and led the establishment and development of the pharmacology teaching (lectures, practicals and tutorials) within the pharmacy degree course.  He was also involved in the development of the pharmacology component of the certificate in nurse prescribing within the School of Nursing, RCSI. He has also been a member of the RCSI Research Committee since 2006.  In 2009 Dr Kirby completed a Masters in Leadership and Management at RCSI.

He has organised the All-Ireland Schools of Pharmacy Research Conference on two occasions (2007 and 2011) and has been invited to present guest lectures at a number of institutes.  He has also served as an external examiner for PhD and MSc theses. In addition, Dr. Kirby has been involved with the HSE Addiction Services for many years and has been closely involved in a number of developments within addiction services.  He is also a member of the Addiction Services Drugs and Therapeutics Committee.Dr. Kirby’s research is centred around the development of models of neurodegenerative disease and schizophrenia and he has a number of active collaborations in these areas.

Kirby BP, Pabari, R, Chen, CN, Al Baharna, M, Walsh, J, Ramtoola, Z (2013) Comparative evaluation of the degree of pegylation of PLGA nanoparticles in enhancing CNS delivery of loperamide. Journal of Pharmacy and Pharmacology, 65(10), 1473-1481.

Solinsky, C and Kirby, B. P. (2013) Medial prefrontal cortex lesions in the mouse do not impair effort based decision making. Neuropharmacology, 65, 223-231.

O’Donnell A. Baneham S., Pabari R., Kirby B.P., Ramtoola Z. (2011) Enhancing Cell Penetration using Surfacemodified Nanoparticles: Enhancing Drug Delivery to the Central Nervous System (CNS) J Pharm Pharmaceut Sci, 14(3) 207s-208s.

Solinsky, C and Kirby, B. P. (2013) Medial prefrontal cortex lesions in the mouse do not impair effort based decision making. Neuropharmacology, 65, 223-231.

O’Tuathaigh C.M., Desbonnet L., Moran P.M., Kirby B.P., Waddington J.L. (2011) Molecular Genetic Models Related to Schizophrenia and Psychotic Illness: Heuristics and Challenges. Curr Top Behav Neurosci. 7, 87-119

Ramtoola, Z., Lyons, P., Keohane, K., Kerrigan, S.W., Kirby, B.P., Kelly, JG. (2011) Investigation of the interaction of biodegradable micro- and nanoparticulate drug delivery systems with platelets J. Pharm. Pharmacol., 63, 26-32.

O’Tuathaigh, C.M., Kirby, B.P., Moran, P.M., Waddington, J.L. (2010) Mutant Mouse Models: Genotype-Phenotype Relationships to Negative Symptoms in Schizophrenia. Schizophr Bull. 36(2), 271-288.

Bunk, E.C., Konig, H.-G., Bonner, H.P., Kirby, B.P., Prehn, J.H. (2010) NMDA-induced injury of mouse organotypic hippocampal slice cultures triggers delayed neuroblast proliferation in the dentate gyrus: An in vitro model for the study of neural precursor cell proliferation. Brain Research, 1359, 22-32.

Bunk, E.C., Konig, H.G., Bernas, T., Engel, T., Henshall, D.C., Kirby, B.P., Prehn, J.H.M (2010) BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus. Cell Death and Disease. 1, e15; doi:10.1038/cddis.2009.13

Kirby, B.P., Waddington, J.L., O’Tuathaigh, C.M. (2010) Advancing a functional genomics for schizophrenia: Psychopathological and cognitive phenotypes in mutants with gene disruption. Brain Res Bull. 83(3-4), 162-176.

Kennedy, M., O’Neill, S., Kirby, B.P. (2008) Water quality in the reconstitution of oral antibiotics. Irish Pharmacy Journal, 86(Aug-Sept), 196-197.

Dr Kirby’s research has always centred on neuroscience and, more particularly, behavioural neuropharmacology. While he has experience in different neurological conditions – cerebral ischaemia, Alzheimer‘s disease, schizophrenia and neurogenesis – the underlying skills are surgical and behavioural, used to model CNS disease and develop novel models for use in research.

Collaborations:

  • Universiti Putra Malaysia
  • Monash University, Malaysia
  • Malaysian Agricultural Research and Development Institute (MARDI)
  • University of Oxford
  • Royal College of Surgeons in Ireland
  • National University of Ireland, Galway
  • National University of Ireland, Maynooth